Neurogenic Inflammation and Sensitive Skin
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Neurogenic Inflammation and Sensitive Skin

Dr. Nirvana S.Pillay

Sensitive skin is not always “weak skin.” In many cases, it is skin with a lower irritation threshold, driven by a combination of barrier vulnerability and increased nerve reactivity.

Read the Brain–Skin Connection pillar.

What Is Neurogenic Inflammation?

Neurogenic inflammation describes inflammatory changes influenced by sensory nerves in the skin. When nerves are more reactive, they can amplify redness, itch, stinging, and discomfort — especially during stress or after irritant exposure.

Why Sensitive Skin Can Flare During Stress

  • Stress lowers tolerance: the skin may react to products that were previously fine.
  • Barrier strain increases: dryness and water loss can rise when the barrier is under pressure.
  • Nerves signal more easily: sensations like burning or stinging become more likely.

Common Triggers for Neuro-Reactive Skin

  • over-exfoliation and frequent acid use
  • hot showers and heat exposure
  • fragrance sensitivity (varies by person)
  • sleep deprivation
  • rapid routine changes

How to Support Sensitive, Neuro-Reactive Skin

  1. Reduce variables: keep routines consistent for 2–4 weeks.
  2. Barrier-first products: focus on comfort and compatibility.
  3. Limit exfoliation: sensitivity often improves when exfoliation is reduced.
  4. Patch test: introduce one new product at a time.
  5. Regulation habits: short daily downshifts (breathing, walking, sleep wind-down) support skin tolerance.

FAQs

Is sensitive skin linked to the nervous system?

Often, yes. Skin is densely innervated and can react more strongly when stress signaling is elevated or the barrier is strained.

Why does my moisturizer suddenly sting?

Stinging can happen when the barrier is compromised or nerves are sensitized. Simplifying the routine and focusing on barrier support can help.

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